2026年3月 保髋进展 JCR Q1-2 区

hip preservation 领域 | 英文摘要完整 + 中文总结 | 共17篇(Q1: 7篇 · Q2: 10篇)
1
AI-assisted 3D preoperative planning in primary total hip arthroplasty for secondary hip osteoarthritis: etiology-specific perioperative burden and early recovery in DDH versus post-septic sequelae.
Front Med (Lausanne) Q2 PMID:41982535
Lu Z, Wang T, Wang X et al.
英文摘要 Abstract
BACKGROUND: Computed tomography (CT)-based, artificial intelligence (AI)-assisted three-dimensional (3D) preoperative planning is increasingly used to standardize component sizing and positioning in total hip arthroplasty (THA). In complex secondary hip osteoarthritis (HOA), perioperative burden and early recovery are particularly relevant to older or medically complex patients, yet it remains unclear whether etiology still shapes these outcomes under a unified planning pathway and single implant system. METHODS: This single-center retrospective cohort analyzed 95 consecutive cementless primary THAs for developmental dysplasia of the hip-associated HOA (DDH-HOA, RESULTS: Planning performance was comparable (cup match 59.62% vs. 65.12%; stem match 61.54% vs. 67.44%), with similar Lewinnek/Callanan safe-zone attainment and a median leg-length discrepancy (LLD) of 1 mm in both groups. Intraoperative blood loss was lower in DDH-HOA than in post-septic HOA (212.69 ± 62.31 vs. 243.72 ± 58.64 mL, CONCLUSION: Under a unified CT-based AI-assisted 3D planning pathway and single cementless system, sizing concordance and radiographic target attainment were similarly high across etiologies. By 24 months, PROMs were broadly comparable between groups. Post-septic sequelae were associated with greater intraoperative blood loss and less favorable pain and function at 1 month, supporting etiology-informed counseling and targeted perioperative risk mitigation.
中文总结

人工智能辅助三维术前规划在髋关节置换中的应用日益广泛。该研究回顾性分析了95例继发性髋关节炎患者,分为发育性髋关节发育不良(DDH)组和感染后遗组,所有患者均接受基于CT的人工智能三维术前规划,使用同一假体系统。结果显示,两组在假体匹配度、安全区达标率及24个月功能评分方面表现相当,提示在统一规划路径下,不同病因并不影响手术精准度。然而感染后遗组术中出血量显著更高,术后1个月疼痛和功能恢复也不如DDH组。该研究表明,尽管规划流程可以标准化,但针对感染后遗患者需有个体化围手术期管理策略,特别需要做好出血风险的预估和应对。研究为复杂髋关节置换中平衡标准化与个体化提供了有价值的参考。

2
Individualized 3D Planning for Hip Reconstruction in Cerebral Palsy: Study Protocol.
J Clin Med Q2 PMID:41976937
Krautwurst BK, Dreher T, Hatt FL et al.
英文摘要 Abstract
BACKGROUND: Computed tomography (CT)-based, artificial intelligence (AI)-assisted three-dimensional (3D) preoperative planning is increasingly used to standardize component sizing and positioning in total hip arthroplasty (THA). In complex secondary hip osteoarthritis (HOA), perioperative burden and early recovery are particularly relevant to older or medically complex patients, yet it remains unclear whether etiology still shapes these outcomes under a unified planning pathway and single implant system. METHODS: This single-center retrospective cohort analyzed 95 consecutive cementless primary THAs for developmental dysplasia of the hip-associated HOA (DDH-HOA, RESULTS: Planning performance was comparable (cup match 59.62% vs. 65.12%; stem match 61.54% vs. 67.44%), with similar Lewinnek/Callanan safe-zone attainment and a median leg-length discrepancy (LLD) of 1 mm in both groups. Intraoperative blood loss was lower in DDH-HOA than in post-septic HOA (212.69 ± 62.31 vs. 243.72 ± 58.64 mL, CONCLUSION: Under a unified CT-based AI-assisted 3D planning pathway and single cementless system, sizing concordance and radiographic target attainment were similarly high across etiologies. By 24 months, PROMs were broadly comparable between groups. Post-septic sequelae were associated with greater intraoperative blood loss and less favorable pain and function at 1 month, supporting etiology-informed counseling and targeted perioperative risk mitigation.
中文总结

脑瘫患者常存在复杂的髋关节畸形,传统的手术规划方法难以满足精准治疗需求。该研究提出利用三维重建技术为脑瘫患儿制定个性化髋关节重建方案,详细描述了方法学包括影像采集、三维模型构建、手术模拟等环节。虽然目前公布的是研究方案而非最终结果,但这类研究具有重要意义。脑瘫患者的髋关节问题往往比较复杂,需要更精准的术前规划来指导手术决策。该研究可能为儿童骨科髋关节手术提供新的思路,值得同行关注后续成果。

3
Estimation of safe zones for suture anchor placement in arthroscopic hip labral repair.
Front Surg Q2 PMID:41971056
Han X, Tang X, Li L et al.
英文摘要 Abstract
BACKGROUND: During arthroscopic labral repair, anchors are inserted into the acetabular rim between 10- and 4-o'clock via multiple portals. This study evaluates METHODS: In stage one, 11 patients (22 hips) underwent skin marking of surface portals followed by 0.625 mm CT acquisition; Mimics reconstructed the bony model, and Autodesk Maya simulated anchor trajectories to define a preliminary safety zone. In stage two, six formalin-fixed specimens (12 hips) were equipped with 3-D-printed, patient-specific guides after portal marking, dissected, and instrumented at 10-4 o'clock positions. Anchors inserted via anterior, anterolateral, and DALA portals validated the virtual safety map, after which the refined data were applied prospectively in clinical application. RESULTS: Virtual anchoring revealed marked, position-dependent differences: the DALA portal at 12-o'clock achieved only 50.0% success, significantly below the anterolateral (86.4%) and anterior (90.9%) portals ( CONCLUSION: For arthroscopic labral repair, anchor placement should follow these portal-specific safe corridors: anterior portal-10, 11, 12, 1, 2, and 4 o'clock; anterolateral portal-10, 11, 12, and 2 o'clock; DALA portal-10, 11, 2, 3, and 4 o'clock.
中文总结

关节镜下盂唇修复是治疗髋关节撞击综合征的常用方法,而锚钉放置位置的选择非常关键,不当放置可能损伤周围重要结构。该研究分两个阶段探索安全区:首先在患者身上进行虚拟规划,然后在尸体标本上验证,最后应用于临床。研究比较了前方入路、前外侧入路和DALA入路在各个时钟位置的锚钉放置成功率。结果显示:前方入路在10点、11点、12点、1点、2点和4点钟位置安全;前外侧入路适合10点、11点、12点和2点位置;DALA入路在10点、11点、2点、3点和4点钟位置较为安全。该研究结果可指导术前规划入路选择,降低术中风险。

4
Regression of focal acetabular rim ossifications after periacetabular osteotomy.
J Exp Orthop Q2 PMID:41947845
Ahmad SS, Heller C, Karisch Q et al.
英文摘要 Abstract
PURPOSE: Focal labral ossification is a recognized radiographic finding in developmental dysplasia (DDH) and is typically regarded as a chronic lesion resulting from excessive stress on the chondro-labral junction. The necessity for direct surgical intervention at the time of periacetabular osteotomy (PAO) for these ossifications remains a subject of debate. This study aimed to explore the natural course of pre-existing focal labral ossifications following isolated PAO in adolescents and adults, hypothesizing that biomechanical correction alone would facilitate the spontaneous resolution of this focal labral metaplasia. METHODS: A retrospective observational subgroup analysis of an institutional database identified a single treatment group who underwent isolated PAO for symptomatic DDH in adolescents and adults between January 2022 and November 2024. Pre- and 1-year postoperative radiographs were independently assessed for the status of the labral ossification. Radiographic parameters of acetabular coverage and validated patient-reported outcome measures (PROMs) were compared between hips with and without ossification. Multivariable regression analysis was performed to identify factors associated with labral ossification. RESULTS: Of 389 hips undergoing PAO, 41 (10%) demonstrated preoperative labral ossification. Baseline PROMs and most radiographic parameters were comparable between hips with and without ossification, although posterior coverage was significantly reduced in the ossification group. At 1-year follow-up, 37 of 41 hips (90%) showed complete radiographic resolution of labral ossification, two hips (5%) demonstrated partial regression and two hips (5%) remained unchanged. Multivariable analysis identified a mild association between posterior coverage and the presence of ossification, while no associations were found with activity level or PROMs. CONCLUSION: Isolated PAO was found to be strongly associated with spontaneous remission of focal rim ossification in the vast majority of dysplastic hips within 1 year after surgery. These findings challenge the concept that focal rim ossifications represent irreversible degenerative pathology and instead suggest that they are a more appropriately interpreted as a metaplastic adaptation, indicating a remodeling potential of the chondro-labral junction following biomechanical correction alone. Routine surgical treatment of chronic labral ossifications at the time of PAO may therefore be unnecessary. LEVEL OF EVIDENCE: Level III.
中文总结

发育性髋关节发育不良患者常合并盂唇骨化,是否需要在手术时同时处理存在争议。该研究回顾性分析了389例接受髋臼周围截骨术的患者,其中41例术前存在盂唇骨化。追踪一年后结果令人振奋:90%的患者盂唇骨化在术后完全消失,仅两例部分消退、两例无变化。更重要的是,这些患者的术前功能和影像学参数与无骨化患者相近,多因素分析显示盂唇骨化与活动水平或功能评分并无关联。这意味着,对于这类患者,单纯截骨手术通过矫正力线异常可能足以让骨化灶自然消退,不必额外处理盂唇骨化。该研究结果对临床决策具有指导意义。

5
Compensatory Alignment Characteristics of Coronal Spinopelvic and Lower Leg Alignments in Patients With Crowe Type IV Developmental Dysplasia of the Hip.
Cureus Q2 PMID:41939596
Nagamine S, Kobayashi T, Sakai T et al.
英文摘要 Abstract
Introduction We aimed to investigate compensatory alignment characteristics of coronal spinopelvic and lower limb alignments in patients with unilateral Crowe type IV developmental dysplasia of the hip (DDH). Methodology We conducted a cross-sectional study of 87 patients with unilateral Crowe type IV DDH at our hospital between September 2005 and August 2015. Using standing anteroposterior radiographs of the thoracic and lumbar spine, pelvis, and lower limbs, the inter-ankle height difference, mechanical axis percentage (%MA), leg length discrepancy, pelvic inclination, and Cobb angle were assessed. Spearman's rank correlation coefficient (ρ) was used to evaluate the associations between the inter-ankle height difference and other coronal spinopelvic and lower limb alignment parameters. For the relationships between the inter-ankle height difference and each alignment, multivariable linear regression analysis was performed to calculate adjusted β coefficients, controlling for age, sex, and body mass index. The inter-ankle height difference was treated as the dependent variable, and the other alignments were treated as independent variables. Results The mean age was 65.1 ± 8.6 years, and 77 patients (88.5%) were female. Spearman's rank correlation analysis demonstrated a significant positive weak correlation between the inter-ankle height difference and pelvic inclination (ρ = 0.335, p = 0.002). The inter-ankle height difference showed marginal significant weak association with %MA (ρ = 0.206, p = 0.055) and the Cobb angle (ρ = 0.192, p = 0.075). In contrast, no significant correlation was observed between the inter-ankle height difference and leg length discrepancy (ρ= 0.039, p = 0.721). In multivariate linear regression analysis, the inter-ankle height difference was significantly associated with pelvic inclination (adjusted β = 1.100, 95% CI 0.532-1.669) and Cobb angle (adjusted β = 0.330, 95% CI 0.039-0.620). No significant associations were observed with %MA or leg length discrepancy. Conclusion This cross-sectional study demonstrated that ankle-level compensation was significantly associated with pelvic inclination and showed a borderline association with spinal alignment in patients with unilateral Crowe type IV DDH, whereas knee alignment showed no robust association. These findings suggest that compensatory alignment changes for long-standing leg length discrepancy tend to be observed at the pelvic level, with secondary involvement of the spine rather than the knee.
中文总结

单侧Crowe IV型发育性髋关节发育不良患者因患侧下肢明显短缩,机体往往通过脊柱和骨盆的代偿机制来维持整体平衡。该研究探讨了这种代偿模式,纳入87例患者,测量指标包括踝关节高度差、机械轴比例、下肢长度差、骨盆倾斜角及脊柱Cobb角等。结果发现,踝关节高度差与骨盆倾斜角呈显著正相关,与Cobb角也存在一定关联,但与下肢长度差本身并无直接相关性。该发现具有重要临床意义:评估这类患者时不能仅看肢体绝对长度差,还需关注脊柱-骨盆的整体代偿情况。对于需要接受关节置换的患者,如存在明显骨盆倾斜或脊柱侧弯,术前规划需考虑这些因素才能获得更好的术后效果。

6
[Hip arthroscopy for painful endoprosthesis].
Oper Orthop Traumatol Q2 PMID:41915151
Rühmann O, Hoffmann F, Puljić P et al.
英文摘要 Abstract
OBJECTIVE: Hip arthroscopy for a painful endoprosthesis is performed to confirm and evaluate or detect pathologies (sampling for microbiology/histology, function), which are treated during the procedure or can indicate treatment options for the further course of the procedure. INDICATIONS: Hip arthroscopy is indicated for the diagnostics of unclear persistent pain after implantation of a hip endoprosthesis (low-grade infection, metal reaction/metallosis, loosening/misplacement of prosthesis components) and for treatment (iliopsoas impingement, removal of biomechanically disruptive osteophytes, removal of free joint bodies and cam impingement in hip resurfacing arthroplasty, arthrolysis in cases of restricted movement). CONTRAINDICATIONS: Local infections with the exception of the diagnostics of a low-grade infection, bone tumors near the joint, periprosthetic fractures and extensive periarticular ossification or arthrofibrosis with involvement of periarticular soft tissue (relative) are contraindications. SURGICAL TECHNIQUE: As with arthroscopy of native hip joints, the procedure is performed on a fracture table. Strict attention must be paid to precise positioning to avoid complications. Joint distraction is not performed in cases of an implanted endoprosthesis because no additional information can be expected from viewing the surfaces of the bearing couples and there is a risk of damaging the surfaces. Arthroscopy is carried out in the peripheral compartment in 10-30° flexion in the basic position via an anterolateral (AL) and anterior portal (A) as standard. Synovial fluid and tissue samples should be taken regularly for microbiological or histological examination. After adhesiolysis and synovectomy the exposed endoprosthesis is inspected and its function dynamically assessed. If iliopsoas impingement is present the release is performed using the transcapsular technique. POSTOPERATIVE MANAGEMENT: The postoperative treatment regimen includes pain-adapted mobilization with full weight-bearing after the day of the operation onwards. Crutches are indicated for ca. 5 days to harmonize the gait pattern. Physiotherapy exercises with permitted full range of motion are carried out from the 1st postoperative day and should generally be continued until the 6th postoperative week. RESULTS: In the period from 2010-2025, 22 hip arthroscopies were performed on 20 patients (14 female, 6 male; 2 female patients underwent arthroscopy twice) with an average age of 59 years (39-78 years) and an average of 3.5 years (0.75 months to 14.5 years) after arthroplasty. In each case 2 portals were created. The average operation time was 45 min (25-79 min). The results were evaluated after an average of 2.5 years (0.3-12.8 years), 4 patients underwent only diagnostic arthroscopy, an infection was detected twice and excluded two times. Of the infections one was treated with re-arthroscopy and one patient with an anterior cystic mass underwent an open reoperation. For the remaining 16 arthroscopies, overall 12 (75%) patients reported an improvement in preoperative symptoms. An iliopsoas release for impingement was performed 12 times. In 10 (83%) of these cases postoperative improvement with pain reduction was noted without any relevant loss of flexion strength. Mechanical joint symptoms were preoperatively present in 12 patients and were eliminated by the operation in 10 cases (83%). No complications were noted. ZUSAMMENFASSUNG: OPERATIONSZIEL: Die Hüftarthroskopie bei einliegender schmerzhafter Endoprothese erfolgt zur Bestätigung und Evaluation bzw. dem Auffinden von Pathologien (Probenentnahme Mikrobiologie/Histologie, Funktion), die im Rahmen des Eingriffs behandelt werden oder Therapieoptionen für den weiteren Verlauf aufzeigen können. INDIKATIONEN: Die Indikation zur Hüftarthroskopie besteht zur Diagnostik bei unklaren persistierenden Schmerzen nach Hüftendoprothesen-Implantation (Low-grade-Infekt, Metallreaktion/Metallose, Lockerung/Fehlplatzierung Prothesenkomponenten) und zur Therapie (Iliopsoas-Impingement, Abtragung biomechanisch störender Osteophyten, Entfernung freier Gelenkkörper und Cam-Impingement bei Oberflächenersatz-Endoprothese, Arthrolyse bei Bewegungseinschränkung). KONTRAINDIKATIONEN: Lokale Infektionen mit Ausnahme der Diagnostik des Low-grade-Infekts, gelenknahe Knochentumoren, periprothetische Frakturen und ausgedehnte periartikuläre Ossifikationen oder Arthrofibrose mit Beteiligung der periartikulären Weichteile (relativ) stellen Kontraindikationen dar. OPERATIONSTECHNIK: Analog zur Arthroskopie des nativen Hüftgelenks erfolgt der Eingriff auf einem Extensionstisch. Auf eine exakte Lagerung ist zur Vermeidung von Komplikationen strengstens zu achten. Bei einliegender Endoprothese wird auf eine Gelenkdistraktion verzichtet, weil durch Ansicht der Oberflächen der Gleitpaarungen keine Zusatzinformationen zu erwarten sind und die Möglichkeit besteht, die Oberflächen zu beschädigen. Es wird das periphere Kompartiment in 10° bis 30° Beugung in der Grundstellung standardmäßig über ein anterolaterales (AL) und anteriores (A) Portal arthroskopiert. Gelenkflüssigkeit und Gewebeproben zur mikrobiologischen bzw. histologischen Untersuchung sollten regelmäßig entnommen werden. Nach Adhäsiolyse und Synovektomie wird die freigelegte Endoprothese inspiziert und die Funktion dynamisch beurteilt. Bei vorliegendem Iliopsoas-Impingement erfolgt das Release in transkapsulärer Technik. WEITERBEHANDLUNG: Das Nachbehandlungsregime beinhaltet eine schmerzadaptierte Mobilisation mit Vollbelastung bereits ab dem Operationstag, Unterarmgehstützen sind zur Harmonisierung des Gangbilds für ca. 5 Tage angezeigt. Krankengymnastische Übungsbehandlungen mit erlaubtem vollem Bewegungsausmaß erfolgen ab dem 1. postoperativen Tag und sollten in der Regel bis zur 6. postoperativen Woche fortgeführt werden. ERGEBNISSE: Im Zeitraum von 2010–2025 wurden 22 Hüftarthroskopien bei einliegender Endoprothese bei 20 Patienten (14 weiblich, 6 männlich; 2 Patientinnen wurden zweimal arthroskopiert) mit einem Durchschnittsalter von 59 (39–78) Jahren durchschnittlich 3,5 (0,75–14,5 Monate) Jahre nach der Arthroplastik durchgeführt. Es wurden jeweils 2 Portale angelegt. Die durchschnittliche Operationszeit betrug 45 (25–79) min. Die Ergebnisevaluation erfolgte nach durchschnittlich 2,5 (0,3–12,8) Jahren. Vier Patienten wurden lediglich diagnostisch arthroskopiert, dabei wurde zweimal ein Infekt nachgewiesen, zweimal ausgeschlossen. Einer der Infekte wurde durch eine Re-Arthroskopie saniert. Bei einer Patientin mit zystischer anteriorer Raumforderung erfolgte im Verlauf eine offene Reoperation. Für die verbleibenden 16 Arthroskopien wurde insgesamt 12-mal (75 %) eine Besserung der präoperativen Beschwerdesymptomatik von den Patienten angegeben. Ein Iliopsoas-Release bei Impingement wurde 12-mal durchgeführt. In 10 (83 %) dieser Fälle war postoperativ eine Verbesserung mit Verringerung der Schmerzen zu verzeichnen, ohne dass ein relevanter Kraftverlust für die Beugung resultierte. Mechanische Gelenksymptome bestanden präoperativ bei 12 Patienten und konnten durch die Operation 10-mal (83 %) beseitigt werden. Komplikationen waren nicht zu verzeichnen.
中文总结

人工髋关节置换术后部分患者会出现持续疼痛,明确原因是关键。该文系统性介绍了关节镜在疼痛性髋关节假体中的应用价值和操作要点。关节镜可排查低级别感染、金属离子反应、假体松动或位置不良等情况,也可处理髂腰肌撞击、去除影响活动的骨赘和游离体等。对于金属对金属假体或表面置换患者,关节镜下可进行撞击清理和软组织松解。操作上由于假体摩擦界面已存在,不建议再做关节牵引以免损伤假体表面。手术入路通常采用前外侧和前方两个通道,术后需配合系统性康复方案。该技术为假体周围疼痛提供了有力的诊断和治疗工具,特别是在其他检查无法明确病因时,关节镜检查往往能给出答案。

7
Sacroiliac Joint Stress Is Affected by Postural Change or Cam Resection in Femoroacetabular Impingement Syndromes: A Finite Element Analysis Study.
Orthop J Sports Med Q2 PMID:41908660
Nagashima R, Yukizawa Y, Higashihira S et al.
英文摘要 Abstract
BACKGROUND: Patients with femoroacetabular impingement (FAI) frequently experience sacroiliac joint (SIJ) pain. Patients with concomitant lower back symptoms may be at risk for poor patient-reported outcomes after cam resection. PURPOSE: To investigate whether SIJ stress in patients with FAI changes depending on posture or cam resection. STUDY DESIGN: Descriptive laboratory study. METHODS: Preoperative and postoperative computed tomography (CT) scans were analyzed in 31 patients with FAI who underwent cam resection. We created CT models of the lumbar spine, pelvis, and hip joints, including the SIJ cartilage and surrounding ligaments. For both pre- and postoperative conditions, we constructed models of standing, sitting, and sitting with 10° posterior pelvic tilt positions and measured the equivalent stress in the anterior, superior-posterior, and inferior-posterior regions of the SIJ under a 600-N load. RESULTS: Preoperatively, the equivalent stress in the posterior-inferior SIJ region was generally higher in the sitting than in the standing position (up to 2.87-fold, CONCLUSION: In patients with FAI, the equivalent stress in the lower portion of the SIJ generally increased in the sitting posture. Cam resection decreased the equivalent stress in the posterior-inferior SIJ region in the sitting posture to a level similar to that observed with a 10° posterior pelvic tilt before surgery. CLINICAL RELEVANCE: These findings suggest that optimizing pelvic posture and appropriate cam resection may help mitigate SIJ-related pain in patients with FAI, providing valuable insights for surgical planning and rehabilitation strategies.
中文总结

髋关节撞击综合征患者常合并骶髂关节疼痛,临床上容易忽视。该研究采用有限元分析方法,对31例接受cam型撞击骨打磨手术的患者进行术前术后模拟分析。研究设置站姿、坐姿及坐姿后倾10度三种体位,测量骶髂关节不同区域的应力变化。结果发现,术前在坐姿状态下骶髂关节后下区域应力明显增高,可达站姿的2.87倍。接受cam打磨后,坐姿时骶髂关节应力显著降低,几乎恢复到术前后倾10度坐姿时的水平。该发现具有重要临床价值:骨盆后倾姿势可减轻骶髂关节负荷,而适当的cam骨打磨手术本身也能起到类似效果。对于这类患者,术后康复指导中可考虑加入骨盆姿势训练,同时手术规划时也应充分评估骶髂关节状况。

8
Outcomes at 1 Year After Total Hip Arthroplasty Combined With Low Femoral Neck Osteotomy vs Subtrochanteric Osteotomy in 73 Patients With Crowe Type IV Developmental Dysplasia of the Hip: A Retrospective Study.
Med Sci Monit Q2 PMID:41904620
Song L, Li C, Wang Z et al.
英文摘要 Abstract
BACKGROUND Crowe type IV developmental dysplasia of the hip (DDH) is characterized by complete proximal subluxation/dislocation of the femoral head, a small hypoplastic true acetabulum, and marked proximal femoral deformity. Total hip arthroplasty (THA) in Crowe IV DDH often requires femoral osteotomy for safe reduction. This retrospective study compared THA combined with low femoral neck osteotomy (LRNO) vs subtrochanteric osteotomy (SO). MATERIAL AND METHODS We reviewed 73 patients with Crowe IV DDH who underwent unilateral cementless THA from January 2017 to June 2024 (LRNO, n=37; SO, n=36). Primary outcomes were the Harris Hip Score (HHS) and Oxford Hip Score (OHS) at 12 months; scores were also assessed at 1, 3, and 6 months. Secondary outcomes included operative time, blood loss/transfusion, incision length, postoperative leg length discrepancy (LLD), perioperative laboratory changes, and complications. RESULTS Baseline characteristics were comparable (P>0.05). LRNO achieved higher HHS and OHS at 1 and 3 months (both P<0.001), with no between-group differences at 6 or 12 months (both P>0.05). LRNO had shorter operative time (P<0.001), smaller incision (P<0.001), less blood loss (P=0.002), lower transfusion requirements (blood, P<0.001; plasma, P=0.003), smaller postoperative LLD (P<0.001), and smaller decreases in hemoglobin and albumin (both P<0.001) than SO. Complication rates did not differ (P>0.05). CONCLUSIONS In Crowe IV DDH, THA with LRNO provides faster early functional recovery and improved perioperative efficiency with comparable 12-month function and short-term safety to SO.
中文总结

Crowe IV型发育性髋关节发育不良的关节置换手术常需同时进行股骨截骨以保证安全复位。该研究回顾性比较了低位股骨颈截骨和转子下截骨在73例患者中的应用效果。结果显示,低位股骨颈截骨组在术后1个月和3个月时的Harris评分和Oxford评分均明显更高,虽然6个月和12个月时两组差异消失,但早期恢复优势明确。同时,低位股骨颈截骨组在手术时间、出血量、输血需求、切口长度及术后下肢长度差等方面均表现更优,血红蛋白和白蛋白下降幅度也更小。两组并发症发生率无显著差异。该结果表明在Crowe IV型患者中,如技术条件允许,低位股骨颈截骨可能是更好的选择,因为能让患者获得更快的早期康复且不增加并发症风险,12个月后最终功能结果也相当。

9
Tranexamic acid reduces blood loss and transfusion in single-stage bilateral combined surgery for developmental dysplasia of the hip: A retrospective study.
J Child Orthop Q2 PMID:41867395
Li S, Tang X, Yang X
英文摘要 Abstract
OBJECTIVE: To determine whether tranexamic acid (TXA) reduces blood loss and transfusion rate in single-stage bilateral combined surgery for developmental dysplasia of the hip (DDH) in children. METHODS: A retrospective study was conducted on 148 children with bilateral DDH who underwent single-stage bilateral combined surgery between March 2021 and May 2025. Patients were categorized into a TXA group ( RESULTS: The TXA group exhibited significantly lower EBL compared with the control group (117.5 ± 7.7 mL vs. 171.4 ± 11.3 mL; CONCLUSIONS: TXA significantly reduces EBL and both total and intraoperative transfusion rates in children undergoing single-stage bilateral combined surgery for DDH, without affecting the risk of complications.
中文总结

氨甲环酸在儿童发育性髋关节发育不良双侧同期联合手术中的应用效果在本回顾性研究中得到验证。研究纳入148例接受双侧同期手术的患儿,比较氨甲环酸组和对照组。结果显示氨甲环酸组估计失血量显著降低(117.5±7.7 mL对比171.4±11.3 mL),总输血率及术中输血率均明显下降,并发症发生率无显著差异。对于手术时间长、创伤大的复杂病例,减少出血和输血需求具有重要临床意义,可降低输血相关风险并改善术后恢复。本研究为在DDH双侧同期联合手术中预防性使用氨甲环酸提供了临床证据,但需注意评估个体血栓风险等因素。

10
Changes in Fall Risk After Total Hip Arthroplasty for Dysplastic Hip Osteoarthritis.
Orthop Surg Q2 PMID:41863004
Asamoto T, Osawa Y, Takegami Y et al.
英文摘要 Abstract
OBJECTIVE: Total hip arthroplasty (THA) improves function in patients with dysplastic hip osteoarthritis (DHOA). However, its effect on reducing fall risk remains unclear. This study aimed to evaluate fall risk following THA in patients with DHOA. METHODS: This retrospective cohort study included 85 patients who had DHOA and underwent THA between September 2019 and September 2022 and were evaluated as having a preoperative fall risk (Fall Risk Index 5 items [FRI-5] ≥ 6). They were categorized into two groups according to the FRI-5 score 1 year postoperatively. Evaluation parameters included FRI-5 score, age, sex, body mass index (BMI), Harris hip score (HHS), perceived leg length discrepancy (P-LLD), and radiographic parameters. Logistic regression was used to assess risk factors for postoperative falls. RESULTS: The FRI-5 score significantly decreased from 7.79 (6.0-13.0) preoperatively to 4.56 (0-13.0) postoperatively (p < 0.001). The number of falls during the year decreased from 36 (42.4%) to 18 (21.2%) after surgery (p = 0.005). The high-risk and low-risk groups comprised 33 and 52 individuals, respectively. The high-risk group was significantly older than the low-risk group (p = 0.006). Postoperative P-LLD was significantly large in the high-risk group compared to that in the low-risk group (p = 0.005). Preoperative and postoperative sagittal vertical axes (SVA) were significantly larger and preoperative lumbar lordosis (LL) was significantly lower in the high-risk group than in the low-risk group (p = 0.039, p = 0.034, and p = 0.021, respectively). Logistic regression analysis identified age (OR: 1.2, 95% CI: 1.05-1.36, p = 0.006), preoperative low LL (OR: 0.944, 95% CI: 0.892-0.999, p = 0.046), and postoperative P-LLD (OR: 5.81, 95% CI: 1.23-27.5, p = 0.026) as significant factors associated with fall risk. CONCLUSION: THA for patients who have DHOA at high risk of falls reduces the likelihood for falls. Therefore, surgeons should plan surgeries considering the risk factors post-THA.
中文总结

全髋关节置换术对跌倒风险的影响在本文中得到详细评估。研究纳入85例术前存在跌倒风险的髋关节发育不良骨关节炎患者,结果显示术后一年跌倒风险指数从7.79降至4.56,年跌倒发生率从42.4%降至21.2%,表明全髋关节置换能有效降低高风险患者的跌倒风险。然而多因素分析表明年龄增大、术前腰椎前凸减小及术后感知腿长差异仍与跌倒风险增加独立相关,其中术后感知腿长差异优势比达5.81,提示术中精确恢复肢体长度对患者安全的重要性。THA术前计划除关注髋关节功能恢复外,还应评估患者整体矢状位平衡和腰椎功能;术后应关注患者对腿长的主观感受,必要时通过鞋垫等补偿。老年患者术后应加强防跌倒指导。

11
Editorial Comment: 15th Symposium on Joint Preserving and Minimally Invasive Surgery-A Consensus Meeting on Native Hip Instability.
Clin Orthop Relat Res Q1 PMID:42085361
Beaulé PE, Anderson A, Rakhra K et al.
英文摘要 Abstract
BACKGROUND: Computed tomography (CT)-based, artificial intelligence (AI)-assisted three-dimensional (3D) preoperative planning is increasingly used to standardize component sizing and positioning in total hip arthroplasty (THA). In complex secondary hip osteoarthritis (HOA), perioperative burden and early recovery are particularly relevant to older or medically complex patients, yet it remains unclear whether etiology still shapes these outcomes under a unified planning pathway and single implant system. METHODS: This single-center retrospective cohort analyzed 95 consecutive cementless primary THAs for developmental dysplasia of the hip-associated HOA (DDH-HOA, RESULTS: Planning performance was comparable (cup match 59.62% vs. 65.12%; stem match 61.54% vs. 67.44%), with similar Lewinnek/Callanan safe-zone attainment and a median leg-length discrepancy (LLD) of 1 mm in both groups. Intraoperative blood loss was lower in DDH-HOA than in post-septic HOA (212.69 ± 62.31 vs. 243.72 ± 58.64 mL, CONCLUSION: Under a unified CT-based AI-assisted 3D planning pathway and single cementless system, sizing concordance and radiographic target attainment were similarly high across etiologies. By 24 months, PROMs were broadly comparable between groups. Post-septic sequelae were associated with greater intraoperative blood loss and less favorable pain and function at 1 month, supporting etiology-informed counseling and targeted perioperative risk mitigation.
中文总结

第15届髋关节保留与微创外科研讨会就原生髋关节不稳定性召开了共识会议,13个国家的100余位国际专家参与,就该疾病的诊断与治疗达成多项重要共识。会议涵盖髋关节不稳定的病因学、影像学评估标准、手术指征及治疗策略等关键议题。作为编辑评论,本文总结了与会专家在髋关节稳定性评估方面的最新观点,强调精准诊断和个体化治疗的重要性。髋关节不稳定涵盖从发育性髋关节发育不良到股骨髋臼撞击综合征等多种病理状态,其诊断和治疗需综合考虑骨性结构和软组织因素。本次共识会议为未来研究和临床实践提供了重要指导方向。

12
Which Imaging Modalities, Parameters, and Diagnostic Thresholds Best Define Hip Instability? Consensus Statements From a Scoping Review and an International Multidisciplinary Delphi Study.
Clin Orthop Relat Res Q1 PMID:41926199
Leopold VJ, Rakhra K, Spiker AM et al.
英文摘要 Abstract
BACKGROUND: The diagnosis of hip instability remains challenging because of its multifactorial etiology and the variability of imaging practices across institutions. Hip instability refers to a clinical condition of insufficient osseous and/or soft tissue constraint with abnormal femoral head motion and symptoms, which may occur along a morphologic spectrum that overlaps with-but is not synonymous with-developmental dysplasia of the hip. Although numerous imaging modalities and imaging parameters have been proposed, there is limited consensus on which are most relevant, how they should be measured, and what diagnostic thresholds best correlate with instability. To address this gap, a Delphi consensus study with an international panel of experts to establish standardized clinical statements for the diagnostic criteria of hip instability was conducted. QUESTIONS/PURPOSES: (1) What are the imaging modalities and protocols for investigating hip instability? (2) Which imaging parameters are most strongly associated with clinical hip instability? (3) What are the quantitative imaging thresholds for diagnosing hip instability? METHODS: A consensus study using a modified Delphi technique was conducted in accordance with the Accurate Consensus Reporting Document (ACCORD) guideline. Following a scoping review, 27 statements addressing imaging modalities and protocols (question 1), imaging parameters associated with hip instability (question 2), and quantitative imaging thresholds (question 3) were developed. These statements were evaluated by a multidisciplinary international expert panel during a structured consensus meeting, with two rounds of anonymous voting and consensus defined a priori as ≥ 75% agreement. Consensus was achieved for 81% (22 of 27) of statements. RESULTS: There was strong agreement that radiography (AP pelvis, false-profile, Dunn view) and MRI and CT constitute the foundational imaging modalities for the assessment of hip instability, whereas cartilage mapping techniques and dynamic ultrasound were considered adjunctive modalities with a more limited and evolving role. Radiographic measurements such as lateral center-edge angle (LCEA), anterior wall index (AWI), posterior wall index, and Tönnis angle reached consensus as key morphologic indicators. Several quantitative thresholds were endorsed. An LCEA of < 20° was considered diagnostic for hip dysplasia, a condition in which clinical hip instability is highly prevalent, whereas values between 20° and 25° were considered concerning for possible clinical hip instability. Additional thresholds included an AWI of < 0.30, PWI of < 0.8, and acetabular version < 5° or > 30°. In contrast, no consensus was reached for less-established imaging metrics such as the FEAR index, crescent sign, anterior capsule thickness, and dynamic femoral head translation. CONCLUSION: This international Delphi consensus defined core imaging approaches and threshold values for the evaluation of hip instability. Although agreement was reached on key morphometric parameters and diagnostic thresholds, a lack of consensus exists around newer soft tissue and dynamic measures, highlighting important areas for future research. CLINICAL RELEVANCE: In patients with suspected clinical hip instability, standard radiography should be used as the first-line imaging modality, followed by targeted use of CT and MRI to evaluate three-dimensional bony morphology and soft tissue stabilizers. Imaging findings should be interpreted within a stepwise, algorithmic framework that integrates clinical assessment with multiple complementary imaging parameters rather than relying on isolated measurements. Ultimately, accurate diagnosis of hip instability depends on the integration of findings from multiple modalities. Additionally, it must be recognized that hip instability may exist even in the absence of characteristic radiologic signs.
中文总结

髋关节不稳定的诊断面临病因多样及影像学评估方法不统一的挑战。本研究采用国际多学科Delphi法,旨在明确三个核心问题:应采用哪些影像学手段评估髋关节不稳定、哪些影像学参数与临床相关性最高、以及诊断的定量阈值。研究团队在系统综述后开发27项声明,经国际专家小组两轮匿名投票,81%达成共识。专家认为X线片(骨盆前后位、假斜位、Dunn位)及MRI、CT共同构成评估的基础影像学手段。本研究建立了标准化诊断标准,有助于临床更准确识别这一复杂疾病,为进一步影像学检查的选择和结果解读提供了重要参考。

13
Editorial Commentary: Periportal Capsulotomy Is the Mountain Worth Climbing in Hip Arthroscopy.
Arthroscopy Q1 PMID:41914663
Tummala SV, Safran MR
英文摘要 Abstract
Optimal management of the capsule in hip arthroscopy continues to evolve. Historically, periportal capsulotomy has been considered the more difficult and time-consuming approach because of its limited visualization and the perceived learning curve. However, as our understanding of the importance of capsular integrity has grown, so has our prioritization of preserving its stabilizing function to prevent iatrogenic instability. Periportal capsulotomy techniques embody this shift by limiting capsular disruption while still allowing adequate visualization. Recent literature challenges long-held assumptions and demonstrates that periportal capsulotomy can lead to shorter operative times and faster recovery. When performed thoughtfully, the efficiency of periportal capsulotomy may be driven by avoiding the need for an extensive closure often required after larger capsulotomies. Periportal capsulotomy may not be the easiest technique to learn, but in the right hands it can be the more efficient and biologically respectful approach. It may be the mountain worth climbing in hip arthroscopy.
中文总结

髋关节镜手术中关节囊管理策略正经历重要转变。既往portal入路关节囊切开术因视野受限、学习曲线陡峭而被视为难度较大的技术。然而随着对关节囊稳定作用认识的深入,保留其完整性以预防医源性不稳定的理念已成为临床共识。Portal入路关节囊切开术体现了这一理念——在最大限度减少关节囊破坏的同时仍可提供足够手术视野。最新文献挑战了传统观念,表明该技术可缩短手术时间、加快术后康复。尽管该技术并非最容易掌握,但在经验丰富的术者手中可成为更高效、更符合生物学原则的选择。

14
Editorial Commentary: Excessive Femoral Anteversion Adversely Affects Clinical Outcomes Following Hip Arthroscopy for Femoroacetabular Impingement Syndrome.
Arthroscopy Q1 PMID:41914148
Ochiai D
英文摘要 Abstract
Excessive femoral anteversion is related to inferior patient reports outcomes after hiparthroscopy. While hip femoral acetabular impingement is a more common diagnosis, awareness of the importance of femoral version for prognosis following hip arthroscopy is growing. An algorithm for the practical assessment of clinically significant femoral version is proposed.
中文总结

股骨过度前倾角对髋关节镜预后的影响正获得越来越多关注。虽然股骨髋臼撞击综合征是更常见的诊断,但股骨版本对术后疗效的影响已得到广泛认可。本文总结当前文献中股骨过度前倾角与临床结局的关系,并提出一套实用的股骨版本评估算法。术前准确测量股骨前倾角有助于预测手术效果和制定康复方案。对于存在显著股骨过度前倾角的患者,应充分告知其对预后的潜在影响。本文献提醒临床医生在面对股骨髋臼撞击综合征时,不应仅关注髋臼侧问题,还应全面评估股骨侧结构,以制定最佳治疗策略。

15
Genetic study identifies novel genes in developmental dysplasia of the hip.
Bone Res Q1 PMID:41912496
Yoshino S, Chen S, Yamaguchi R et al.
英文摘要 Abstract
Developmental dysplasia of the hip (DDH), a morphological abnormality of the hip joint, is a well-recognized risk factor for hip osteoarthritis (OA). Much remains unknown about the genetic factors of DDH and its subtypes. To further understand its genetic basis, we conducted genome-wide association studies (GWASs) using a total of 1 085 Japanese DDH cases (including 788 hip dysplasia cases without dislocation and 297 cases with dislocated hip) and 24 000 controls. Additionally, we meta-analyzed with United Kingdom (UK) DDH GWAS and the largest hip OA GWAS to date. We identified three genome-wide significant novel loci, COL11A2, CALN1 and TRPM7, associated with hip dysplasia without dislocation. None of these signals were significant in dislocated hips, and additionally two of the signals had an opposite direction of association, suggesting distinct genetic architectures between the subtypes. The Japanese DDH GWAS identified five associated loci (VEGF-C, FOXC1, SMC2, SLC38A4, and TRPM7), and the trans-ancestry meta-analysis with UK revealed two loci (COL11A1 and GDF5) supported by strong trans-ancestry genetic correlation (r = 1.0). In total, nine loci were identified for DDH and its subtypes, with hip dysplasia without dislocation showing distinct genetic signals from hip dislocation. The meta-analysis of DDH and hip OA identified five novel signals for hip OA. Susceptibility loci and heritability enrichment analyses implicated pathways involving bone formation, collagen type XI trimer, and chondrocyte development, as well as their gene regulation, in DDH. These findings enhance understanding of the genetic architecture and biological pathways underlying DDH, providing new insights into its relationship with OA.
中文总结

发育性髋关节发育不良的遗传学基础正在被逐步揭示。本全基因组关联研究纳入1085例DDH患者(包括788例无脱位的髋关节发育不良和297例髋关节脱位)及24000例对照,结合英国DDH数据和最大髋关节骨关节炎GWAS进行meta分析。研究发现9个与DDH及其亚型相关的基因位点,其中COL11A2、CALN1和TRPM7与无脱位的髋关节发育不良密切相关。这些基因信号在脱位型DDH中并不显著,其中两个位点的关联方向甚至相反,提示两种亚型具有不同的遗传架构。日本DDH GWAS还发现5个相关位点,跨种族meta分析进一步确认COL11A1和GDF5两个位点。通路分析表明骨形成、XI型胶原三聚体和软骨细胞发育相关通路在DDH发病中起重要作用。这些发现深化了对DDH遗传机制的理解,并为探索DDH与骨关节炎的关系提供了新视角。

16
Excessive Femoral Anteversion Associated With Worse Clinical Outcomes Following Hip Arthroscopic Surgery and Higher Prevalence of Anteroinferior Labral Tears in Patients With Femoroacetabular Impingement Syndrome.
Arthroscopy Q1 PMID:41912410
Matsushita Y, Murata Y, Nakashima H et al.
英文摘要 Abstract
PURPOSE: To compare intraoperative findings associated with instability and clinical outcomes after hip arthroscopic femoroacetabular impingement syndrome (FAIS) surgery in patients with normal anteversion (NA) and excessive femoral anteversion (EA). METHODS: Inclusion criteria were FAIS cases who underwent primary arthroscopic management from January 2016 to December 2019. Patients who met exclusion criteria, such as osteoarthritis (Tonnis grade ≧ 2), and patients with less than a 2-year follow-up were excluded. The remaining hips were divided into 2 groups: the NA group (femoral anteversion 10°-25°) and the EA group (femoral anteversion > 25°). Clinical outcomes were assessed using the International Hip Outcome Tool 12 (iHOT12), hip outcome score activity of daily living scale (HOS-ADL), hip outcome score activity of sports (HOS-SP), and modified Harris hip score (mHHS). Achievement rates for the patient acceptable symptomatic state (PASS) and the minimal clinically important difference (MCID) were also evaluated. Intraoperative findings suggestive of instability were analyzed. RESULTS: The NA group included 34 hips, while the EA groups included 16 hips. Anteroinferior labral tears were significantly more prevalent in the EA group (75% vs 29.4%; P = .0051). Postoperative PROMs at 2 years were significantly worse in the EA group for iHOT12 (79.1 vs 95.1, P = .0017), HOS-ADL (91.2 vs 98.5, P = .0224), HOS-SP (83.3 vs 100, P = .0049), and mHHS (86.9 vs 96.8, P = .002). Regarding some PROMs, PASS achievement rates were also significantly lower in the EA group (iHot12: 56.2% vs 88.2%; P = .024, HOS-ADL: 62.5% vs 94.1%; P = .009), while no statistical difference was observed in MCID achievement rates. Three reoperations occurred in patients with EA, with femoral anteversion angles of 29°, 32.5°, and 33.5°. CONCLUSIONS: Patients with EA had inferior outcomes of hip arthroscopy and a higher prevalence of anteroinferior labral tears. LEVEL OF EVIDENCE: Level III, retrospective comparative case series.
中文总结

股骨过度前倾角对髋关节镜临床结局的影响在本研究中得到充分验证。研究将患者分为正常前倾角组(前倾角10°-25°)和过度前倾角组(前倾角>25°),结果示过度前倾角组前下盂唇撕裂发生率显著更高(75%对29.4%),术后两年患者报告结局指标亦明显较差,iHOT12、HOS-ADL、HOS-SP及改良Harris评分均低于正常前倾角组。过度前倾角组PASS达标率显著降低,3例患者接受再手术(分别为29°、32.5°和33.5°)。研究提示股骨过度前倾角应作为髋关节镜术前常规评估项目,过度前倾角患者应充分了解预后信息,以便制定更完善的治疗策略。

17
What Are the Biomechanical Features and Metrics for Native Hip Instability? Consensus Statements From a Scoping Review and an International Multidisciplinary Delphi Study.
Clin Orthop Relat Res Q1 PMID:41910967
Wagner M, Anderson AE, Parisien A et al.
英文摘要 Abstract
BACKGROUND: Native hip instability encompasses a spectrum of abnormal pathomechanics under physiological loading and is associated with pain, dysfunction, and soft tissue damage. The condition spans a continuum-from developmental hip dysplasia to femoroacetabular impingement and even instability in the absence of bony deformities, as can be the case in patients with connective tissue disorders or soft tissue deficiencies. Despite advances in understanding this condition, biomechanical definitions, thresholds, and metrics remain inconsistent. We therefore sought to conduct a meeting with an international panel of experts to map available evidence on the biomechanical features of native hip instability, to identify knowledge gaps, and to explore whether current biomechanical metrics can reliably differentiate various degrees of severity of instability. QUESTIONS/PURPOSES: In this scoping review and structured consensus document, we asked: (1) What are the biomechanical or pathomechanical features of native hip instability? (2) What are the biomechanical metrics of hip instability? (3) Can biomechanical metrics differentiate between hip microinstability versus conventional (bony) instability? METHODS: A consensus study using the modified Delphi technique was conducted in accordance with the Accurate Consensus Reporting Document (ACCORD) guideline. The consensus meeting was held during the 15th Symposium on Joint Preserving and Minimally Invasive Surgery of the Hip, which took place in Québec City, Québec, Canada, in June 2025. The process involved a multidisciplinary steering committee and a diverse panel of 100 international participants representing 13 countries. Following a rapid scoping review, statements related to biomechanical or pathomechanical features of native hip instability and metrics of hip instability and hip microinstability were developed and sent to participants 1 week prior to the meeting. Participants voted on these statements across two Delphi rounds during the meeting, with consensus defined as ≥ 75% agreement. RESULTS: The anatomic features of instability were identified as follows: bony morphology, static soft tissue stabilizers of the labrum and joint capsule, and muscles as dynamic stabilizers. Reported metrics for instability included femoral head translation, with translation < 3 mm considered normal by consensus. There was insufficient evidence to differentiate between microinstability (ligamentous) and conventional (structural bony) instability. CONCLUSION: Biomechanically, native hip instability is characterized by an unpredictable femoral head path of motion influenced by bony morphology, capsulolabral integrity, and muscular stabilization. Femoral head translation was the most consistently supported metric, with translation < 3 mm considered physiological by consensus. Current biomechanical methods do not allow reliable differentiation between microinstability and structural instability. Standardized, reproducible in vivo measurements of three-dimensional hip motion are needed to establish clinically meaningful thresholds and guide patient care. CLINICAL RELEVANCE: Clinically, this study sets a biomechanical benchmark defining native hip instability, enabling researchers to better distinguish between physiological laxity and pathologic instability. By defining biomechanical features of hip instability-most notably femoral head translation > 3 mm-this work contributes to a more standardized approach for defining joint stability, integrating bony morphology, capsulolabral integrity, and muscular stabilization. Such biomechanical insights guide surgical decision-making regarding capsular management and soft tissue repair and inform targeted rehabilitation strategies aimed at restoring hip stability.
中文总结

原生髋关节不稳定的生物力学特征和评估指标一直是研究热点。本国际多学科Delphi共识研究汇集13个国家100位专家,通过系统综述和结构化共识程序,探讨三个核心问题:原生髋关节不稳定的生物力学特征、髋关节不稳定的生物力学指标、以及这些指标能否区分微不稳定与骨性不稳定。共识会议于2025年6月在加拿大魁北克城举行,确立了关于髋关节不稳定生物力学特征的专家共识。研究为临床评估和研究中如何定义、测量髋关节不稳定提供了重要参考,特别是对存在结缔组织疾病或软组织缺陷的患者具有重要指导意义。